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Scientists discover a protein that silences the biological clock

Press releases may be edited for formatting or style | June 05, 2015

"There are vast consequences to trying to live outside the natural daily cycle," Partch said. "We know that clock disruption in general is not a good thing, and we have ongoing studies to explore its role in cancer and other human health problems."

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The first author of the Molecular Cell paper on PASD1 is Alicia Michael, a graduate student in Partch's lab. Other coauthors include Stacy Harvey, Patrick Sammons, and Hema Kopalle at UC Santa Cruz, and Amanda Anderson and Alison Banham at Oxford. This work was supported by grants from the UC Cancer Research Coordinating Committee, the U.S. National Institutes of Health, and the U.K. Cancer Research Programme, and a Paul & Anne Irwin Cancer Research Award to Alicia Michael.

The first authors of the Nature Structural & Molecular Biology paper on Cryptochrome are Chelsea Gustafson, a graduate student in Partch's lab, and Haiyan Xu at the University of Memphis. Other coauthors include Patrick Sammons, Nicole Parsley and Hsiau-Wei (Jack) Lee at UC Santa Cruz, and additional collaborators at the University of Memphis. This work was funded by the National Institutes of Health and the National Science Foundation.

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