"Our findings are particularly intriguing and provide a unique, more individualized approach to managing men receiving SRT after radical prostatectomy (RP)," said lead study author Robert Den, MD, assistant professor of radiation oncology at Sidney Kimmel Medical College at Thomas Jefferson University. "Indeed, the GC biomarker provides an insight regarding tumor aggressiveness in these individuals. Despite salvage local therapy for recurrent prostate cancer after RP, some patients continue to progress to metastases. Identifying these men may allow them to undergo systemic therapy, including testing novel therapies to reduce the risk of metastases. And, the men at low risk of progression can be spared treatment intensification, such as high dose hormone therapy, which may lead to permanent side effects."

The abstract, "Validation of a Genomic Classifier for Prediction of Metastasis Following Postoperative Salvage Radiation Therapy" will be presented in detail during a scientific session at ASTRO's 57th Annual Meeting at 1:15 p.m. Central time on Wednesday, October 21, 2015.


To speak with Dr. Den, please call Nancy Mayes on October 18-21, 2015, in the ASTRO Press Office at the Henry B. González Convention Center, in San Antonio at 210-258-8104 or 210-258-8105, or email press@astro.org.

ASTRO's 57th Annual Meeting, to be held at the Henry B. González Convention Center in San Antonio, October 18-21, 2015, is the nation's premier scientific meeting in radiation oncology. The 2015 Annual Meeting is expected to attract more than 11,000 attendees including oncologists from all disciplines, medical physicists, dosimetrists, radiation therapists, radiation oncology nurses and nurse practitioners, biologists, physician assistants, practice administrators, industry representatives and other health care professionals from around the world. Led by ASTRO President Bruce D. Minsky, MD, FASTRO, a radiation oncologist specializing in gastrointestinal cancers, Professor of Radiation Oncology, and the Frank T. McGraw Memorial Chair at The University of Texas MD Anderson Cancer Center, Houston, the theme of the 2015 Meeting is "Technology Meets Patient Care." Dr. Minsky's Presidential Symposium, "Multidisciplinary Management of Esophageal and Rectal Cancers," will feature Leonard L. Gunderson, MD, MS, FASTRO, and Joel E. Tepper, MD, FASTRO, to highlight imaging, staging, genomics and data mining approaches, as well as the latest advances in esophageal and colorectal cancer treatment. ASTRO's four-day scientific meeting includes presentation of more than 2,100 abstracts: up to four plenary papers, 351 oral presentations, 1,609 posters and 171 digital posters in more than 52 educational sessions and 26 scientific panels for 20 disease-site tracks. Three keynote speakers will address a range of topics including cancer biology in radiation oncology, the essential roles of a physician, and patient safety: Arul Chinnaiyan, MD, PhD, Professor and Director, Michigan Center for Translational Pathology; Francisco G. Cigarroa, MD, Past President and Chancellor, University of Texas; and Gerald B. Hickson, MD, Senior Vice President and Assistant Vice Chancellor, Vanderbilt University Medical Center.

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