Michael Fautsch, Ph.D., Mayo Clinic; Harry Orr, Ph.D., University of Minnesota
Smart Fabric for Cardio-Performance Enhancement
Compression garments have widespread clinical and commercial applications, but garments on the market today suffer from several design flaws. This research team is developing a smart garment with integrated active materials with the ability to squeeze on command, combining the controllability and ease of donning an inflatable sleeve with the low mass/profile of an elastic stocking. Applications range from vascular disease therapies to sports medicine.
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Lucy Dunne, Ph.D., University of Minnesota; Bruce Johnson, Ph.D., Mayo Clinic
Regenerating Myelin in Multiple Sclerosis
MS is a complicated progressive disease that affects almost one in every thousand people around the world. These researchers will be using newly patented DNA aptamers that help mice to regenerate material damaged by animal MS to study disease progression. Aptamers are specialized molecules that bind to pre-selected targets. Researchers will test how best to assemble these aptamers for treatment, and whether a simpler method to ease the drug manufacturing process will be effective. These studies with mice will set the stage for moving this important new MS therapy toward future studies with humans.
Jim Maher, Ph.D., Mayo Clinic; Sang-Hyun Oh, Ph.D., University of Minnesota
Molecular Mechanism of Novel Small Molecule Therapeutics for Alzheimer’s disease
This project hopes to establish more efficient treatment regimens for memory loss. It will take a novel therapy (CP2/C458) and determine if it can slow or stop actual loss of nerve cells caused by the toxic proteins that cause Alzheimer’s disease.
Michael Lee, Ph.D., University of Minnesota; Eugenia Trushina, Ph.D., Mayo Clinic
Early Diagnosis of Brain Insulin Resistance in Alzheimer’s disease
It is shown that in type II diabetes and similarly, in Alzheimer’s disease, blood vessels in the brain are damaged and insulin needed for proper brain function cannot be delivered to the brain. Researchers in this project will work on developing insulin as an imaging marker for the early detection of the blood vessels’ inability to transport insulin into the brain. This will allow health professionals to screen individuals at risk for dementia before the memory changes become evident.
Karunya Kandimalla, Ph.D., University of Minnesota; Val Lowe, M.D., Mayo Clinic
The Minnesota Partnership for Biotechnology and Medical Genomics is a collaboration between the University of Minnesota, Mayo Clinic and the state of Minnesota. To learn more about the Partnership, visit http://www.minnesotapartnership.info.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to medical research and education, and providing expert, whole-person care to everyone who needs healing. For more information, visit http://www.mayoclinic.org/about-mayo-clinic or http://newsnetwork.mayoclinic.org/.
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