MRI Identifies 'Hidden' Fat That Puts Adolescents at Risk for Disease

by Barbara Kram, Editor | February 27, 2007

According to Dr. Siegel, fat tissue estimation through single-slice MRI is simple, fast and could be useful in many clinical and research applications, including patient management, monitoring interventions, and implementing multi-center clinical trials or epidemiologic studies.

"Our ability to accurately measure abdominal fat may substantially advance strategies for achieving healthy weights in children," she said.

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Radiology is a monthly scientific journal devoted to clinical radiology and allied sciences. The journal is edited by Anthony V. Proto, M.D., School of Medicine, Virginia Commonwealth University, Richmond, Va. Radiology is owned and published by the Radiological Society of North America, Inc. (RSNA.org/radiologyjnl)

The Radiological Society of North America (RSNA) is an association of more than 40,000 radiologists, radiation oncologists, medical physicists and related scientists committed to promoting excellence in radiology through education and by fostering research, with the ultimate goal of improving patient care. The Society is based in Oak Brook, Ill. (RSNA.org)

"Measurement of Total and Intra-abdominal Fat Distribution in Adolescents by Magnetic Resonance Imaging." Collaborating with Dr. Siegel on this paper were Charles F. Hildebolt, D.D.S., Ph.D., Kyongtae T. Bae, M.D., Cheng Hong, Ph.D., M.D. and Neil H. White, M.D., C.D.E.

Full Caption:
Figure 1: MR images in 10-year-old overweight girl.
Upper left: Transverse true FISP abdominal MR image (4.3/2.1; flip angle, 58 degrees; matrix, 256 x 150; section thickness, 10 mm) acquired as part of standard MR examination. From this image, a pixel was selected within subcutaneous or visceral fat region. Lower left: Subcutaneous fat region. Lower right: Visceral fat region. Fat regions were segmented separately with region-based thresholding segmentation method, and areas were measured. Upper right: Total abdominal fat was calculated (not directly measured) as the sum of measured subcutaneous fat and measured intraabdominal fat. We measured the entire abdomen to have a denominator for the computation of percentage of abdominal fat (total abdominal fat/entire abdomen), which was compared with DXA measurement.

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