Discussing the value of MR-guided radiotherapy

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Discussing the value of MR-guided radiotherapy

by Gus Iversen, Editor in Chief | September 03, 2019
Rad Oncology
Parag Parikh
From the September 2019 issue of HealthCare Business News magazine

Q&A with Parag Parikh, director of MR-Guided Radiation Therapy and director of GI Radiation Oncology
Henry Ford Cancer Institute


Last November, Dr. Parag Parikh, joined the radiation oncology department at Henry Ford Cancer to lead its MR-guided radiation program. HealthCare Business News sat down with him to find out how the new role is working out and why he feels that MR-guided radiation is such a promising field for the future of cancer treatment.

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HCB News: Can you tell us a bit about your background in radiation oncology and what it's been like to join the team at Henry Ford?
Parag Parikh: I attended medical school and residency at Washington University in St. Louis. I had an early interest in technology development for tracking moving tumors and worked under Dr. Daniel Low to investigate CT scanning of lung tumor respiratory motion and implantable electromagnetic transponders that could be put into the lung to help guide radiation therapy.

I continued as a faculty member at Washington University for 12 years, and our team treated the first MR-guided radiation therapy patient in the world in 2014. With the novel adaptive MR-guided radiation therapy trial by Drs. Lauren Henke and Jeff Olsen, we realized that abdominal radiation therapy would never be the same.

I returned home to Detroit to join Henry Ford in 2018. As the group with the longest-running clinical MR-linear accelerator program, it was like jumping into a well-running automobile. We now have a one month waitlist for the ViewRay and we have doubled our therapy staff to support this.

HCB News: We've been hearing a lot recently about the cutting-edge capabilities of MR-guided radiation therapy. This is a field where Henry Ford is at the cutting edge. What kind of research are you currently conducting with these tools?
PP: We have several ongoing clinical trials. First, we are leading the national SMART study [NCT NCT03621644]. This study builds upon retrospective data (Rudra, Cancer Medicine, 2019) showing an almost doubling of survival in patients who received high-dose MR-guided radiation therapy to the pancreas, as compared with standard dose radiation. This is the only study using ablative doses of radiation given over 5 fractions, and has a goal of recruiting 133 patients.

We also have a study using 5 fractions of radiation to treat prostate cancer, using the MRI to help boost the dose of the dominant nodule of prostate cancer in each patient. Finally, we have a corollary study for brain tumor patients looking at new imaging information that may inform how or when to change radiation therapy for glioblastoma.

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