by
Barbara Kram, Editor | January 30, 2008
Subsequently, the scientists found that miR-21 expression tracked tumor stage - the more advanced the tumor, the greater the amount of miR-21 present - indicating that it may play a role in cancer development and progression and could, therefore, serve as a good drug development target. Comparisons of tumor stage, miR-21 expression, and clinical outcome in patients with stage II or III colon cancer also revealed associations between high levels of miR-21 and poor survival, poor therapeutic outcome, and, in patients who experienced a disease relapse, more rapid recurrence.
"To the best of our knowledge, this is the largest study done so far comparing microRNA profiles and clinical outcomes in colon cancer, and the only one to use tissues and data from two independent groups," Harris noted. These data build both a rationale for using expression of these five microRNAs as a prognostic tool in colon cancer and lend weight to a role for miR-21 in colon cancer development and treatment."
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For more information on Dr. Harris's laboratory, please go to http://ccr.cancer.gov/staff/staff.asp?profileid=5761.
For more information about cancer, please visit the NCI Web site at http://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
The most effective way to prevent colorectal cancer or detect it early is to begin regular screening. For more information about colorectal cancer screening, please visit the CDC website at http://www.cdc.gov/cancer/colorectal/.
The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
Reference:
Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yeun ST, Chan TL, Kwong DLW, Au GKH, Liu C, Calin GA, Croce CM, and Harris CC. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinomas. JAMA, January 30, 2008, Vol. 299, No. 4.
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