"The main purpose of this study was to see if intensive therapy would reduce the death rate, shorten the duration of the illness, and decrease the number of new complications in other organs among patients with acute kidney injury," said co-author Robert A. Star, M.D., director of NIDDK's Division of Kidney, Urologic and Hematologic Diseases. "Though this was found not to be the case, it is important that we know this so we can focus future research on finding more beneficial treatment strategies."
"Unlike earlier studies that used only a single method of therapy, our use of an integrated strategy of continuous and intermittent methods of therapy allows us to apply these study results more readily to clinical practice," explained study chair Paul M. Palevsky, M.D., chief of the Renal Section at the VA Pittsburgh Healthcare System and a professor of medicine at the University of Pittsburgh School of Medicine. "What is important about these results is that they outline the limits of effective therapy."
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The VA/NIH Acute Renal Failure Trial Network study, cosponsored by the VA's Cooperative Studies Program (CSP) and NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), enrolled 1,124 critically-ill patients from 17 Veterans Affairs medical centers and 10 university-affiliated medical centers across the United States. The study was conducted from November 2003 through July 2007.
The Cooperative Studies Program is a division of the U.S. Department of Veterans Affairs Office of Research and Development. The CSP's mission is to advance the health and care of veterans through collaborative, multi-center research studies that produce innovative and effective solutions to national healthcare problems. More information about CSP can be found at its website: http://www.csp.research.va.gov.
The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the NIH, conducts and supports research in diabetes and other endocrine and metabolic diseases; digestive diseases, nutrition, and obesity; and kidney, urologic, and hematologic diseases. Spanning the full spectrum of medicine and afflicting people of all ages and ethnic groups, these diseases encompass some of the most common, severe, and disabling conditions affecting Americans. For more information about NIDDK and its programs, see www.niddk.nih.gov.
The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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