The National Cancer Institute (NCI), part of the National Institutes of Health, announced today that it has awarded six grants to collaborative research groups to explore how information derived from comprehensive molecular analyses can be used to impact the care of cancer patients and ultimately improve outcomes. These grants are part of NCI's Strategic Partnering to Evaluate Cancer Signatures (SPECS) program. The molecular signatures of a cell -- identifiable characteristics such as levels or activities of genes, proteins, or other molecular features -- can change as a cell becomes cancerous, signaling the presence of cancer as well as revealing important information about the features of a tumor. The newly funded SPECS grants support multi-institutional, multi-disciplinary research teams that leverage NCI's investment in cancer clinical trials, cancer centers, NCI intramural program, and the SPOREs (Specialized Programs of Research Excellence) program. They also support collaborations with biotechnology companies, community hospitals, the national laboratories, and academic institutions in the United States, Canada and Europe.

NCI has a great interest in the development of new molecular markers that can aid cancer patients and their physicians in the process of clinical decision making. These markers include prognostic markers, which indicate the likelihood of disease outcome regardless of treatment method, and predictive markers, which indicate the likelihood of a patient's response to a specific therapy.

The newly funded SPECS projects are designed to bridge the gap between the discovery and application of molecular profiles by confirming, refining, and evaluating molecular signatures that previously have been demonstrated to be clinically useful. These projects will also focus on developing robust, reproducible assays for specific molecular signatures that will then be tested in clinical trials. The grants, which total $10 million for the first year of funding, were awarded to six multi-institutional, multi-disciplinary teams:
* Children's Hospital, Los Angeles, Calif.
Principal Investigator: Timothy J. Triche, M.D., Ph.D.
This project will refine and validate molecular signatures that provide a more accurate diagnosis and more accurately predict clinical behavior of common childhood sarcomas.

* University of California, Irvine, Calif.
Principal Investigator: Dan Mercola, M.D., Ph.D.
This project will refine and validate molecular signatures that predict relapse in prostate cancer patients and distinguish indolent disease from disease that will progress.

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