Hormonal therapies in the trial are assigned based on menopausal status and include tamoxifen and the aromatase inhibitors anastrozole, letrozole and exemestane. Women on the chemotherapy arm of the trial will receive one of several standard combination chemotherapy regimens considered to be the best available standard care today. It will also be possible for women participating in TAILORx to participate in other NCI-sponsored clinical trials, provided the therapy prescribed in the clinical trial is consistent with their assigned therapy in TAILORx.

Additional goals of this clinical study are to create a tissue and specimen repository for patients enrolled in the trial and to collect follow-up information regarding the health status of those who participate in the study. Tissue collected in this study will be stored for use in future studies to learn more about breast cancer and to evaluate, and potentially refine, diagnostic tests for treatment decisions to an even greater degree than in TAILORx.


With TAILORx, we are taking a big step toward personalized medicine. By using cutting- edge diagnostic tests, well be able to customize an individuals cancer treatment, said Joseph Sparano, M.D., Montefiore Medical Center, Bronx, NY, and Eastern Cooperative Oncology Group protocol chair.

Women in the study will have a physical exam performed by their doctor every three to six months for the first five years, then once a year after that for up to 20 years. An annual mammogram will check for signs of recurrence.

For eligibility and registration information regarding TAILORx, go to http://www.ctsu.org/ and enter TAILORx in the search box.

To view a Q&A on TAILORx, go to http://www.cancer.gov/newscenter/pressreleases/TAILORxQandA.

For a complete set of links and other information related to TAILORx, go to http://www.cancer.gov/clinicaltrials/digestpage/TAILORx.

For more information about the NCI-sponsored clinical trials groups, please visit their Web sites:
http://www.ecog.org
http://ncctg.mayo.edu/
http://www.swog.org
http://www.calgb.org
http://www.acosog.org
http://www.ncic.cancer.ca
http://www.nsabp.pitt.edu

For more information about cancer, please visit the NCI Web site at http://www.cancer.gov, or call NCIs Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).

The National Institutes of Health (NIH) The Nation's Medical Research Agency includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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