Also, awards will support three magnetic resonance imaging (MRI) systems to facilitate the study of human diseases. For example, it will enable cancer, cardiovascular, and metabolic disorder investigations taking place at the University of Pennsylvania. In addition, a new positron emission tomography (PET)/single photo emission computed tomography (SPECT)/computed tomography (CT) scanner will facilitate cancer research at Beth Israel Deaconess Medical Center. Two cryo-electron microscopes will also be funded, including one at Purdue University that will be used to study the structure of viruses. Mouse imaging studies at Massachusetts General Hospital will be advanced with the addition of a magnetic resonance (MR) microscope. Finally, an ultra high-throughput genome sequencing system will support HIV analyses at Stanford University.

More information about the High-End Instrumentation program, including application guidelines, is available at http://www.ncrr.nih.gov/biotech/btheinstr.asp.


FY 2006 High-End Instrumentation Grants:

Beth Israel Deaconess Medical Center (Boston, Mass.) $ 938,175
A positron emission tomography (PET)/single photon emission computed tomography (SPECT)/computed tomography (CT) scanner will support cancer research.

Massachusetts General Hospital (Boston, Mass.) $1,510,934
A high-performance supercomputer will enable investigators to process magnetic resonance imaging (MRI) data from neuroimaging studies of Alzheimer's disease, stroke, and schizophrenia.

Massachusetts General Hospital (Boston, Mass.) $2,000,000
A 15 Tesla, ultra-high field, horizontal magnetic resonance (MR) microscope will facilitate mouse imaging studies of cardiac conditions, diabetes, tissue engineering, and other research projects.

Purdue University (West Lafayette, Ind.) $2,000,000
A 300 kilovolt field emission, cryo-electron microscope will make possible the study of complex biological assemblies, especially viruses.

Stanford University (Stanford, Calif.) $543,750
An ultra high-throughput genome sequencing system that performs clonal amplification and pyrosequencing will support microbial genome sequencing, unbiased explorations of human microbial diversity, and HIV analyses.

University of California, Los Angeles (Los Angeles, Calif.) $1,600,000
A high-end, field emission gun electron microscope will augment structural studies of a broad range of nanomachineries, organelles, viruses and bacterial cells by electron cryomicroscopy (cryoEM) and tomography (ET).

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