"Using heat to kill cancer cells isn't a new concept. The biggest problems with using heat are how to apply it to the tumor cell alone, how to determine its effectiveness and how to predict the amount needed," said DeNardo. "By using heat -- along with nanoparticles and a radiolabeled antibody -- our quantitative imaging directed -- and made safer -- the application and development of therapy for cancer," she added. "This technique could join other cancer therapies, especially for cancers that are hard to treat now, such as breast cancer and metastatic melanoma," indicated DeNardo.

"Thermal Dosimetry Predictive for Efficacy of 111In-ChL6 Nanoparticle AMF-Induced Thermoablative Therapy for Human Breast Cancer in Mice" appears in the March issue of the Journal of Nuclear Medicine, which is published by SNM, the leading international molecular imaging and nuclear medicine society. Co-authors include Gerald L. DeNardo, Arutselvan Natarajan, Laird A. Miers and Grete N. Adamson, all with the School of Medicine, UC Davis, Sacramento; Allan R. Foreman and Robert Ivkov, both with Triton BioSystems Inc., Chelmsford, Mass.; and Cordula Gruettner, Micromod Partikeltechnologie, GmbH, Rostock-Warnemuende, Germany.


About SNM-Advancing Molecular Imaging and Therapy
SNM is an international scientific and professional organization of more than 16,000 members dedicated to promoting the science, technology and practical applications of molecular and nuclear imaging to diagnose, manage and treat diseases in women, men and children. Founded more than 50 years ago, SNM continues to provide essential resources for health care practitioners and patients; publish the most prominent peer-reviewed journal in the field (the Journal of Nuclear Medicine); host the premier annual meeting for medical imaging; sponsor research grants, fellowships and awards; and train physicians, technologists, scientists, physicists, chemists and radiopharmacists in state-of-the-art imaging procedures and advances. SNM members have introduced- and continue to explore-biological and technological innovations in medicine that noninvasively investigate the molecular basis of diseases, benefiting countless generations of patients. SNM is based in Reston, Va.; additional information can be found online at http://www.snm.org/.

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