DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
Current Location:
>
> This Story


Log in or Register to rate this News Story
Forward Printable StoryPrint Comment

 

MRI Homepage

MR shows promise for predicting neurological outcomes in cardiac arrest survivors May also help develop therapies

New research finds brain MR study groups don't reflect U.S. population demographics This must change for large, multicenter studies

Bracco Imaging acquires SurgVision Enables development of a real-time fluorescence image-guided surgery platform

What’s new in MR scanners and coils? A review of new innovations arriving on market

Purchasing Insights: The ABCs of buying an MR Facilities must think about their scanning needs of tomorrow when investing today

Siemens gets 7T MR cleared for clinical use in U.S. MAGNETOM Terra offers benefits for neuro and MSK imaging

Contrasting viewpoints on gadolinium Despite evidence of harm, the industry worries about brain retention

MR detects neurological impairments in newborns with CHD before surgery Detects brain impairments even before cardiac surgery

Anthem presses forward with new MR, CT reimbursement guidelines An effort to increase usage of free-standing scan facilities

Merry X-Ray acquires Consensys Imaging Service Expands presence in MR, CT and other imaging modality markets

Iron oxide pigment
Courtesy of Wikimedia

MIT researchers develop alternative to gadolinium-based MR contrast agents

by Lauren Dubinsky , Senior Reporter
Researchers at the Massachusetts Institute of Technology have developed an alternative to gadolinium-based contrast agents for MR exams. The new iron oxide nanoparticles may be safer for patients with impaired kidney function.

About a third of the 60 million MR procedures performed annually use contrast agents that usually contain gadolinium, according to MIT. Studies have shown that in rare cases gadolinium can cause a potentially fatal condition called nephrogenic systemic fibrosis.

Story Continues Below Advertisement

Because patient safety is the priority

Metrasens is the name top hospitals trust! Click to see how Ferroguard stops threats before Zone 4, or call 630-541-6509



Recent research has shown that gadolinium can accumulate in the brain, but to date it hasn’t been proved to cause any harmful effects. The FDA is currently investigating whether this build up in the brain is harmful.

The MIT researchers found that similar MR contrast can be produced with small iron oxide nanoparticles that have been treated with a zwitterion coating. Zwitterions are molecules that have areas of positive and negative electrical charges that cancel out and make them neutral.

Some contrast agents generate negative or dark areas in the MR image and other produce positive or light areas. The agents that produce light areas contain gadolinium, and iron oxide particles have mostly been used as dark contrast agents.

However, the iron oxide inorganic core is small enough to produce a noticeable positive contrast in MR. Radiologists prefer positive agents because it can be difficult to differentiate certain imaging artifacts and internal bleeding when using negative agents.

Unlike gadolinium-based contrast agents, the coated iron oxide can clear from the kidney quickly and not accumulate. The combination of the very small iron oxide core and the ultrathin ligand shell yields a total hydrodynamic diameter of 4.7 nanometers, which is below the 5.5-nanometer renal clearance threshold.

Initial tests have shown that the iron oxide particle is an effective contrast agent. Going forward, the researchers will perform more toxicology testing to demonstrate the particle’s safety and continue to improve the characteristics of the material.

MRI Homepage


You Must Be Logged In To Post A Comment

Advertise
Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Directory
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Requests
Gold Service Dealer Program
Receive RFP/PS
Requests
Healthcare Providers
See all
HCP Tools
Jobs/Training
Find/Fill
A Job
Parts Hunter +EasyPay
Get Parts
Quotes
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Quotes
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2017 DOTmed.com, Inc.
ALL RIGHTS RESERVED