**Our Clean Sweep Live Auction is NOW LIVE!**

DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
Current Location:
> This Story

Log in or Register to rate this News Story
Forward Printable StoryPrint Comment


MRI Homepage

New MR contrast agent distinguishes aggressive from slow-growing breast cancer Lights up biomarkers in different shades of brightness

Siemens unveils MR for radiation therapy with new magnet, expanded field of view Plus, new high-channel flexible coils for better signal-to-noise ratio

Dr. Linda Pauliks Miller Children's & Women's Hospital Long Beach name medical director of pediatric & congenital cardiac imaging

Study finds MR detects 98 percent of pregnancy-related breast cancers May also inform surgical management of disease

Radiology Partners to acquire Southwest Diagnostic Imaging Joining with SDI 'represents about a 25 percent increase' in RP's size

Michigan appeals court case could test lay-ownership of MR facility laws Must imaging facilities be owned by doctors?

PET/MR scans can assess pediatric cancer survivor health Study targets chemotherapy after-effects in young patients

New guidelines advise against the use of brain imaging to diagnose chronic pain Researchers continue to look for brain-based biomarkers

FDA approves sale of SyMRI IMAGE software for GE Healthcare MR scanners Reduces scan times

FDA panel: Add retention warning to gadolinium contrast agents MIDAC also votes to increase studies conducted by contrast manufacturers

Gadolinium nanoparticles biomineralized
in transferrin proteins

Image courtesy of Nano Letters

Researchers create tumor-targeting MR contrast agent using human proteins

by Lauren Dubinsky , Senior Reporter
Because gadolinium-based contrast agents have been shown to be retained in the brain, the industry has been on a quest to find a viable alternative.

A human protein-based tumor-targeting MR contrast agent that can be easily cleared by the body may be what they’ve been looking for.

Story Continues Below Advertisement

The (#1 Resource) for Medical Imaging and Peripherals. Call 1-949-273-8000

As a Master Distributor for major brands Barco, Philips, and Sony, we offer custom imaging solutions. With our renowned OEM Solutions and Service/Repair Center, Ampronix is a one-stop shop for HD Medical LCD Displays--Printers--Recorders--4K Cameras

A team led by Gang Han, associate professor at the University of Massachusetts Medical School, designed this new contrast agent and found that it holds promise for clinical application. He told HCB News that to the best of his knowledge, it’s the first human protein-based MR contrast.

Sugar has also been investigated as a potential alternative to gadolinium. Research published in Tomography in January and Radiology last month demonstrated that sugar can be used as an MR contrast agent to detect tumors.

Han’s team focused on proteins because they are naturally-occurring nanomaterials. The protein-bound nanoparticle Abraxane, for example, can be used to treat metastatic breast cancer, and protein scaffolds can improve the effectiveness of contrast agents.

In a paper published last month in Nano Letters, Han and his colleagues explained how they created a protein-based contrast agent. They used human transferrin (Tf) proteins to mimic the natural process of forming special nanoparticles called gadolinium biomineralized human Tf protein-based nanoparticles (Gd@TfNP).

The Gd@TfNPs preserve the functions of Tf very well, have superior chemical and physical properties and are brighter, compared to the gadolinium-based agents currently in use, said Han.

Because of that, Gd@TfNPs can be used as systemically clearable contrast agents for detecting early-stage tumors with MR. They can also be used to optimize drug dose and evaluate clinical results.

“This patent of this technology has been submitted,” said Han. “There is already some industry interest since this paper was published.”

MRI Homepage

You Must Be Logged In To Post A Comment

Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Gold Service Dealer Program
Receive RFP/PS
Healthcare Providers
See all
HCP Tools
A Job
Parts Hunter +EasyPay
Get Parts
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to DOTmed.com, Inc. Copyright ©2001-2017 DOTmed.com, Inc.