DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
Current Location:
> This Story

Log in or Register to rate this News Story
Forward Printable StoryPrint Comment



MRI Homepage

FDA clears the Arterys Oncology AI suite Designed for liver MR and CT and lung CT

Study finds patients lack info about imaging exams Researchers uncover what they want to know

Progress on the long road to imaging exam cost transparency New online tools reveal wide range of prices

MR scanner leaks helium at JFK during transport Hazmat team called to the scene

Gadolinium could light way to stroke assessment through the eyes Could eye evaluations replace brain imaging for stroke assessment?

New light detection methods may increase MR imaging sensitivity Could shorten measurement time to obtain anatomical images

Study shows the limitations of machine learning in neuroscience research Functional MR imaging on its own is more accurate

New arrest in fatal MR mishap Metal detectors at the Mumbai hospital were not functioning

FDA greenlights SyMRI NEURO software Makes SyMRI software package available in its entirety in the US

Judge orders imaging firm to pay $16.2 million in False Claims Act lawsuit Administered contrast without proper physician supervision

Gadolinium nanoparticles biomineralized
in transferrin proteins

Image courtesy of Nano Letters

Researchers create tumor-targeting MR contrast agent using human proteins

by Lauren Dubinsky , Senior Reporter
Because gadolinium-based contrast agents have been shown to be retained in the brain, the industry has been on a quest to find a viable alternative.

A human protein-based tumor-targeting MR contrast agent that can be easily cleared by the body may be what they’ve been looking for.

Story Continues Below Advertisement

The (#1 Resource) for Medical Imaging and Peripherals. Call 1-949-273-8000

As a Master Distributor for major brands Barco, Philips, and Sony, we offer custom imaging solutions. With our renowned OEM Solutions and Service/Repair Center, Ampronix is a one-stop shop for HD Medical LCD Displays--Printers--Recorders--4K Cameras

A team led by Gang Han, associate professor at the University of Massachusetts Medical School, designed this new contrast agent and found that it holds promise for clinical application. He told HCB News that to the best of his knowledge, it’s the first human protein-based MR contrast.

Sugar has also been investigated as a potential alternative to gadolinium. Research published in Tomography in January and Radiology last month demonstrated that sugar can be used as an MR contrast agent to detect tumors.

Han’s team focused on proteins because they are naturally-occurring nanomaterials. The protein-bound nanoparticle Abraxane, for example, can be used to treat metastatic breast cancer, and protein scaffolds can improve the effectiveness of contrast agents.

In a paper published last month in Nano Letters, Han and his colleagues explained how they created a protein-based contrast agent. They used human transferrin (Tf) proteins to mimic the natural process of forming special nanoparticles called gadolinium biomineralized human Tf protein-based nanoparticles (Gd@TfNP).

The Gd@TfNPs preserve the functions of Tf very well, have superior chemical and physical properties and are brighter, compared to the gadolinium-based agents currently in use, said Han.

Because of that, Gd@TfNPs can be used as systemically clearable contrast agents for detecting early-stage tumors with MR. They can also be used to optimize drug dose and evaluate clinical results.

“This patent of this technology has been submitted,” said Han. “There is already some industry interest since this paper was published.”

MRI Homepage

You Must Be Logged In To Post A Comment

Increase Your
Brand Awareness
Auctions + Private Sales
Get The
Best Price
Buy Equipment/Parts
Find The
Lowest Price
Daily News
Read The
Latest News
Browse All
DOTmed Users
Ethics on DOTmed
View Our
Ethics Program
Gold Parts Vendor Program
Receive PH
Gold Service Dealer Program
Receive RFP/PS
Healthcare Providers
See all
HCP Tools
A Job
Parts Hunter +EasyPay
Get Parts
Recently Certified
View Recently
Certified Users
Recently Rated
View Recently
Certified Users
Rental Central
Rent Equipment
For Less
Sell Equipment/Parts
Get The
Most Money
Service Technicians Forum
Find Help
And Advice
Simple RFP
Get Equipment
Virtual Trade Show
Find Service
For Equipment
Access and use of this site is subject to the terms and conditions of our LEGAL NOTICE & PRIVACY NOTICE
Property of and Proprietary to, Inc. Copyright ©2001-2018, Inc.