by
John R. Fischer, Senior Reporter | December 29, 2017
"This instrument will enable new forms of multiplexed imaging not previously available to the institute, with the aim to develop, optimize and implement genetically engineered reporter systems for MR with artificial 'multicolor' characteristics," Dr. Amnon Bar-Shir of the department of organic chemistry at the institute, told HCB News at the time of the installation.
Using the system in conjunction with Bruker BioSpec 4.7T MR and Bruker 400 wide-bore spectrometer, the institute hopes to gain a better understanding of the biomolecular processes of certain diseases along with advanced biomaterials that could have potential impact on a variety of emerging diagnostic and therapeutic approaches.
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The scanner enables delivery of superior spectral resolution for functional brain studies and allows users to study low-gamma insensitive nuclei. It also can serve as an imaging platform for an accompanying dissolution DNP hyperpolarizer.
It is the fourth BioSspec 15.2T USR preclinical ultrahigh-field MR system installed in the world.
3) The gadolinium conundrum
In November of this year, actor Chuck Norris and his wife Gena took 11 gadolinium manufacturers to court, claiming that the use of the contrast agent during MR exams “nearly killed her” and caused her to develop Gadolinium Deposition disease that resulted in numerous hospitalizations, amounting to $2 million or more in out-of-pocket costs.
The retention of gadolinium
and the impact of it on the
body is an ongoing debate within
the MR community
Such news jolted public interest in age-old questions on the potential risks and harm brought on by the retention of gadolinium in the body.
A study in June, published in
Radiology,
found that the retention of gadolinium may be more widespread than previously thought, with a team of researchers finding accumulations of gadolinium in five patients who underwent four or more gadolinium-enhanced MR scans. All had normal brain pathology at the time of autopsy.
“Our results suggest current thinking with regard to the permeability of the blood-brain barrier is greatly oversimplified, as gadolinium appears to accumulate even among patients with normal brain tissue and no history of intracranial pathology,” McDonald said in a statement.
