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Ultrasound Homepage

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Purchasing insights for cardiac ultrasound Guidance from the market experts at MD Buyline

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Getting to the heart of cardiac ultrasound technology From premium systems to point of care, an expanding market

Echocardiogram should play role in patient selection for transcatheter mitral valve repair, says study New study highlighted at ACC

Petition calls for removal of 'black box' designation for ultrasound contrast agents Argues that UCAs are safe and "black box" misrepresents risk

Hitachi unveils new CT and ultrasound solutions at ECR Standard version of SCENARIA VIEW and three new Arietta ultrasound solutions

Probo Medical acquires Trisonics Now offers an extensive ultrasound service division

Emerging applications of contrast-enhanced ultrasound in pediatric imaging

From the March 2019 issue of DOTmed HealthCare Business News magazine

By Ryne A. Didier and Anush Sridharan

Pediatric imaging comes with unique challenges, including unpredictable patient cooperation, varying child size and wide breadth of pathology.


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Special-Pricing Available on Medical Displays, Patient Monitors, Recorders, Printers, Media, Ultrasound Machines, and Cameras.This includes Top Brands such as SONY, BARCO, NDS, NEC, LG, EDAN, EIZO, ELO, FSN, PANASONIC, MITSUBISHI, OLYMPUS, & WIDE.



As parents continue to rightfully advocate for their child, concerns regarding invasive procedures, radiation exposure and sedation risks often arise in conversations with clinicians and radiologists. Therefore, being able to obtain diagnostic information using noninvasive technologies with minimal risks is an important and appealing area of shared interest for researchers, clinicians and families.

Ultrasonography (or ultrasound), which uses high-frequency sound waves transmitted through the body to generate images, offers a noninvasive, radiation-free and cost-effective imaging modality. By providing dynamic, real-time visualization of the internal organs and structures, ultrasound (US) affords additional benefits when compared to other diagnostic imaging modalities. However, limitations of US include operator dependence and challenges associated with the patient’s body habitus and scanning characteristics. Furthermore, US employs the Doppler principle to specifically study vascular structures and perfusion defects, but this technique is most sensitive in organs with relatively high blood flow and larger vessels. The discovery and development of US contrast agents has paved the way to overcome some of these limitations and augment diagnostic examinations.

Commonly used US contrast agents consist of gas-filled microbubbles encapsulated by a lipid shell. Their size, typically 1 to 8 microns in diameter, makes them purely intravascular agents that do not diffuse into the interstitial or intracellular space. Contrast-enhanced US (CEUS) relies on the physical interactions between the transmitted US waves and these microbubbles to provide optimal visualization. Administration of the contrast agent can be into the patient’s veins (intravascular) or into a specific cavity (intraluminal/intracavitary). Visualization of the contrast agent is short-lived, on the order of minutes, due to damage by shear forces and instability of the lipid shell. The gas released when the microbubble is destroyed is ultimately expelled by the patient’s lungs. The US contrast agents currently available for medical use in the U.S. have excellent safety profiles and do not cause renal toxicity, which is in contradistinction to the iodine- or gadolinium-based media used in computed tomography (CT) and magnetic resonance (MR) imaging. Advancements in US system software now allow excellent spatial and temporal resolution for real-time CEUS evaluation. These advantages are attractive to pediatric imagers and CEUS has emerged as an incredibly valuable imaging technique.
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