Niskayuna, N.Y., and BOSTON, MASS., October 06, 2005 - GE Global Research and the Frangioni Laboratory at the Beth Israel Deaconess Medical Center (BIDMC) today announced receipt of a $6.5 million grant from The Cancer Imaging Program of the National Cancer Institute (NCI), National Institutes of Health (NIH), to engage in a five-year industrial/academic research collaboration to enhance the imaging of cancerous tumors during surgery.

New breakthroughs in surgical imaging would enable doctors to more clearly identify the location and extent of a tumor during an operation and could ultimately lead to lower cancer recurrence rates in patients, thus improving the quality of care across surgical hospitals. The Frangioni Laboratory has developed an intraoperative imaging system that permits the surgeon to see diseases, such as cancer, using safe, sensitive, but invisible, near-infrared fluorescent light. GE Global Research will leverage its expertise in medical imaging system design and signal processing to increase the sensitivity of the system and to make it compatible with endoscopy and laparoscopy. This will enable deeper visualization into tissue and enable less invasive forms of surgery, decreasing risk and recovery time for patients.

"The biggest question patients and loved ones ask following cancer surgery is; `Did you get it all?'" Steve Lomnes, program leader for biomedical optics, GE Global Research, said. "Through this collaborative research partnership with Beth Israel Deaconess Medical Center, we have an extraordinary opportunity to revolutionize cancer surgery and provide surgeons with the kind of real-time imaging and information they need and give patients the best possible prognosis for a future that is cancer-free. We're very excited about this research partnership and appreciate the NCI's support."
"This highly innovative technology will help surgeons identify and remove all of the tumor during operations," said Marc Zeidel, M.D., chief of medicine at BIDMC. "By seeing where the tumor is and isn't during surgery, the surgeon can get all the tumor while limiting the amount of resection that the patient must recover from. The cancer imaging laboratory defines excellence in translational research by taking what we have learned about cancer biology and using it to develop new ways to see cancers during surgery, in real time."

"We're very excited about this research partnership and the opportunity it will provide to further extend the benefits of imaging technology and analysis into the operating room. We greatly appreciate the NCI's support in this effort," said Herb Kressel, chief of radiology at BIDMC.

An initial design of a prototype imaging system for open surgeries is expected to be complete by the end of the first year of the project. The ultimate goal of the research partnership is to have a fully functional and completed surgical imaging system ready for the clinical stage in five years.

Immediate cancer surgery applications of this enhanced optical imaging system would include: image-guided sentinel lymph node mapping, image-guided cancer resection with real-time assessment of surgical margins, and intraoperative detection of occult metastases in the surgical field.

For more information about GE Global Research, visit www.research.ge.com.

For more information about Beth Israel Deaconess Medical Center, visit
www.bidmc.harvard.edu.

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